Sassafras may refer to:
- Sassafras, a genus of trees native to North America and Asia.
- Sassafras albidum, often called the Sassafras
- Atherospermataceae, or the southern sassafras, trees found in the southern hemisphere.
- Cinnamomum oliveri, known as the black sassafras or Oliver's sassafras; found in Australia
- Slang for Cannabis